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Metal subcellular partitioning determines excretion pathways and sensitivity to cadmium toxicity in two marine fish species. ArchiMer
Le Croizier, Gael; Lacroix, Camille; Artigaud, Sebastien; Le Floch, Stephane; Munaron, Jean-marie; Raffray, Jean; Penicaud, Virginie; Rouget, Marie-laure; Lae, Raymond; Tito De Morais, Luis.
Subcellular cadmium (Cd) partitioning was investigated in the liver of two marine fish species, the European sea bass Dicentrarchus labrax and the Senegalese sole Solea senegalensis, dietary exposed to an environmentally realistic Cd dose for two months followed by a two-month depuration. Cd exposure did not modify Cd cellular partitioning for either species, refuting the spillover hypothesis. Both species contained most of the Cd in the detoxifying fraction but displayed different handling strategies. Cd was largely bound to heat stable proteins (HSP) including metallothioneins (MT) in sea bass while Cd was more linked to metal rich granules (MRG) in sole. Whole liver concentrations and subcellular partitioning were also determined for essential elements....
Tipo: Text Palavras-chave: Sub-cellular fractionation; Dicentrarchus labrax; Solea senegalensis; Essential element distribution; Elimination; Depuration.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00464/57606/59792.pdf
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